Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection

Enterovirus 71 (EV-A71) belongs to the genus Enterovirus of the family Picornaviridae, small viruses characterized by a naked icosahedral capsid and a positive-sense, single-stranded RNA. EV-A71 is the causative agent of hand-foot-and-mouth disease (HFMD), but other clinical manifestations associated with EV-A71 infection range from skin rashes and herpangina to brain stem encephalitis [1]. Recurrent EV-A71 epidemics of various scales have occurred in the Asia-Pacific region [2,3]. Because of its marked neurotropism, following the near complete eradication of poliovirus, EV-A71 may become the greatest threat amongst enteroviruses to cause significant neurological complications [4].

Source: International Journal of Antimicrobial Agents - July 28, 2018 Category: Drugs & Pharmacology Authors: Yipeng Ma, Wenjuan Cong, Hao Huang, Liang Sun, Anh Hung Mai, Kurt Boonen, Wahedi Maryam, Wim De Borggraeve, Guoan Luo, Qingfei Liu, Liliane Schoofs, Frank Van Kuppeveld, Johan Neyts, Carmen Mirabelli, Walter Luyten Source Type: research