Cognitive function of patients with treatment-resistant depression after a single low dose of ketamine infusion

The sequenced treatment alternatives to relieve depression (STAR*D) study reported that up to 40% of patients with major depressive disorder did not achieve symptomatic remission after two trials of traditional antidepressants, which is defined as treatment-resistant depression (TRD). Approximately one-third of patients continued to experience depression after four trials of different antidepressant treatments, including combination therapy and augmentation therapy (Howland, 2008). TRD was commonly coupled with functional impairment, poor quality of life, suicide ideation and attempts, self-injurious behavior, and a high relapse rate (Al-Harbi, 2012).
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research