Use of recombinant Lactobacillus sakei for the prevention and treatment of radiation-induced enteritis
Radiation-induced enteritis is one of the most common complications in patients under radiotherapy at abdominal or pelvic cavity. Up to 50% of patients treated with pelvic radiotherapy has been reported radiation-induced acute enteritis, and half of them developed chronic enteritis. Overproduction of free radicals, activation of inflammatory pathways and vascular endothelial dysfunction were considered as the primary mechanisms of radiation-induced enteritis. Because probiotics have been demonstrated as a promising potential candidate for treating intestinal diseases, it may be a safer and more effective radioprotector for the enteritis compared to conventional chemical agents with inherent toxicities.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Jun-yan He, Wu-zhou Wang, Hui-zhou Qi, Yun Ma, Shu-ya He Source Type: research