Doxycycline and Autogenous Bone in Repair of Critical-Size Defects

Purpose: The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated. Materials and Methods: Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)—blood clot; DOX in Natrosol (NAT)—10% gel; NAT—gel; particulate autogenous bone (PAB); and PAB + DOX − PAB associated with 10% DOX gel. The animals were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was performed to assess the percentage of new bone in the defect area. Statistical analysis of the results was performed using analysis of variance and the Tukey test (P
Source: Implant Dentistry - Category: Dentistry Tags: Basic and Clinical Research Source Type: research