Childhood trauma dependent anxious depression sensitizes HPA axis function

Anxious depression is a common subtype of major depression with a reported proportion ranging between 45-55%. It has been associated with an increased severity (Fava et al, 2004), worse response to treatment (Domschke et al, 2010; Fava et al, 2008), increased suicidality (Tollefson et al, 1994) and increased functional impairment (Joffe et al, 1993). Despite the huge burden and severe consequences DSM-5 does not recognize anxious depression as a diagnostic subtype, but it provides the option to add the specifier “anxious distress”.

Source: Psychoneuroendocrinology - July 26, 2018 Category: Psychiatry Authors: Andreas Menke, Dominik Lehrieder, Jasmin Fietz, Carolin Leistner, Catherina Wurst, Saskia Stonawski, Jannika Reitz, Karin Lechner, Yasmin Busch, Heike Weber, J ürgen Deckert, Katharina Domschke Source Type: research