Inhibitory Effect of fermented pectin on Digestive Enzymes Related to obesity, Hyperlipidemia and hyperglycaemia; and Liver-Kidney tissues toxicities

Publication date: Available online 26 July 2018Source: Bioactive Carbohydrates and Dietary FibreAuthor(s): Khaled Hamden, Mohamed Ali Boujibiha, Nouha ben Abdeljelil, Manel Njima, Lotfi AchourAbstractConsumption of a high fat and sugar diets induced serious disorders and diseases such as obesity, hyperlipidemia and type2 diabetes. Food fibre exerts various beneficial effects in health. The present study evaluate the effect of Soluble Fermentable Dietary Pectin (SFDP) in high-fat/fructose diet (HFFD) induced obesity, hyperlipidemia and hyperglycaemia. The findings indicate that administration of SFDP to HFFD rats improved body weight by decreasing lipase activity in intestine and pancreas by 34 and 22% respectively as compared to untreated HFFD rats; consequently decrease in body weight by 19%; and also decrease in TC and LDL-c and TG rates by 15, 14, and 32% and increase in HDL-c by 32%. In addition, consumption of SFDP significantly suppressed α-amylase activity (key enzyme related to hyperglycaemia) and this leads to decrease in blood glucose level by 24% than those in the diabetic rats. In addition, SFDP efficiently protected the hepatic and kidney functions observed by the considerable decrease of aspartate and alanine transaminases (AST and ALT) and lactate deshydrogenase (LDH), creatinine (Creat) and urea contents in the serum of diabetic rats. The beneficial effects of SFDP were also evidenced histological study of liver,kidney and heart tissues. Overall, the findings...
Source: Bioactive Carbohydrates and Dietary Fibre - Category: Food Science Source Type: research