miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling

AMP-activated protein kinase (AMPK) is a metabolic regulator that acts to limit the growth of cancer cells. AMPK is downregulated by melanoma antigens A3/6 (MAGEA3/6), which are cancer-specific proteins that enhance the activity of specific E3 ubiquitin ligases to ubiquitinate and degrade AMP-activated protein kinase α1 (AMPKα1). Here, using a bioinformatic approach, we identified a microRNA, miR-1273 g-3p, that is predicted to target the 3’ untranslated region (UTR) of MAGEA3/6. Analyzing miR-1273 g-3p expression in human colon cancer tissues, we found a reduction in miR-1273 g-3p expression correlati ng with increased MAGEA3/6 expression and AMPKα1 downregulation.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research