Early weight gain predicts later weight gain in depressed patients treated with antidepressants: findings from the METADAP cohort

Major Depressive Disorder (MDD) is among the diseases that has the greatest impact worldwide on public health (Vigo et al., 2016). It confers a 50% increased mortality of somatic causes (Vos et al., 2012). Antidepressant drugs are the main treatment for Major Depressive Episodes (MDE) in patients with MDD even though antidepressants (AD) use – even newer generations - can induce weight gain (Carvalho et al., 2016). A recent cross- sectional survey without control group on 362 psychiatric patients taking AD for a period ranging from 6 to 36 months found that citalopram, escitalopram, sertraline, paroxetine, venlafaxine, duloxetine and mirtazapine, were associated with significant weight gain (Uguz et al.

Source: Journal of Affective Disorders - July 25, 2018 Category: Neurology Authors: Khalil El Asmar, Bruno F ève, Romain Colle, Florence Gressier, Albane Vievard, Séverine Trabado, Céline Verstuyft, Emmanuel Haffen, Mircea Polosan, Florian Ferreri, Bruno Falissard, Philippe Chanson, Laurent Becquemont, Emmanuelle Corruble Source Type: research