Correlation of cytokines, BDNF levels, and memory function in patients with opioid use disorder undergoing methadone maintenance treatment

The lifetime prevalence rate of opioid use disorder (OUD) is high —2.1% in the US (Grant et al., 2016) and 0.22% globally (Degenhardt et al., 2014)—and is the cause of substantial public health problems throughout the globe (Degenhardt et al., 2014). The development of OUD is associated with multiple genetic, environmental, and developmental risk factors (Volk ow et al., 2016). In addition to the classical etiology for OUD, emerging evidence also suggests that dysregulated neuroinflammation is involved in the development of addiction (Coller and Hutchinson, 2012).

Source: Drug and Alcohol Dependence - July 25, 2018 Category: Addiction Authors: Tzu-Yun Wang, Sheng-Yu Lee, Yun-Hsuan Chang, Shiou-Lan Chen, Po-See Chen, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, I. Hui Lee, Kao Chin Chen, Yen-Kuang Yang, Shih-Heng Chen, Jau-Shyong Hong, Ru-Band Lu Tags: Full length article Source Type: research