Altered levels of brain-derived neurotrophic factor, proBDNF and tissue plasminogen activator in children with posttraumatic stress disorder

Posttraumatic stress disorder (PTSD) is a complex syndrome including intrusive symptoms, persistent avoidance of stimuli, negative alterations in cognitions and mood, and marked alterations in arousal and reactivity associated with the traumatic event (American  Psychiatric Association, 2013). One in six traumatized children on average is reported to have developed PTSD (Alisic et al., 2014). Among trauma types, sexual violence is most likely to be associated with PTSD (Seedat et al., 2004). Previous studies demonstrated that 37 to 53% of children wh o were exposed to sexual abuse developed PTSD (Trask et al., 2011).

Source: Psychiatry Research - July 25, 2018 Category: Psychiatry Authors: Sehra Aksu, Gulsen Unlu, Aysen Cetin Kardesler, Burcu Cakaloz, Hulya Aybek Source Type: research