Positive association between the progression of idiopathic scoliosis and the common variant near the LBX1 gene in Southeast European population

This report investigates the positive association between curve progression of Southeast European population and one of the most significant polymorphisms of idiopathic scoliosis (IS). The association between rs11190870 near the ladybird homeobox 1 (LBX1) gene, the curve severity (case-control study) and the curve pattern (case-only study) was explored among 155 IS Caucasian patients and 254 unrelated controls. The genotyping of rs11190870 was carried out by the TaqMan real-time amplification technology. The results revealed the existence of a statistically significant association between rs11190870, downstream of the LBX1 gene and IS predisposition and progression in the population sample. The case-only analysis indicated also that the genetic variant rs11190870 is not correlated to a certain idiopathic curve pattern. Based on the obtained data, rs11190870 could be regarded as a predisposing and modifying genetic factor for IS in patients of Southeast European descent. In addition, replication studies are necessary to investigate the possible relationship between the LBX1 locus and certain subtypes of IS in specific population groups. Clinical relevance should be pursued further, together with the molecular genetic identification of prognostic markers, as a contemporary approach that would make an early treatment including minimally invasive procedures.Graphical abstract
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research