Glycogen Synthase Kinase-3 β genetic polymorphisms and insomnia in depressed patients: a prospective study

Circadian rhythms are impaired in Major Depressive Episodes (MDE) and in euthymic periods of Major Depressive Disorder (MDD) (Lam, 2008 Sep, Duarte Faria et  al., 2015 Nov 1). Eighty to 90% of patients with MDE have insomnia (Franzen and Buysse, 2008 Dec) and up to 50% have severe insomnia (Costemale-Lacoste et al., 2017 Apr 9). Insomnia may be an endophenotype in MDE. Moreover, while sleep is also regulated by non-circadian processes it could be c onsidered as a clinical marker of circadian rhythm.

Source: Journal of Affective Disorders - July 23, 2018 Category: Neurology Authors: Jean-Fran çois Costemale-Lacoste, Romain Colle, Séverine Martin, Khalil El Asmar, Emanuel Loeb, Bruno Feve, Céline Verstuyft, Séverine Trabado, Florian Ferreri, Emmanuel Haffen, Mircea Polosan, Laurent Becquemont, Emmanuelle Corruble Source Type: research