The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: a review

The presence of cognitive impairments among subjects affected by Bipolar Disorder (BD) in comparison to healthy individuals has been attested by several studies (Mann-Wrobel  et al., 2011), especially in executive functioning, attention, visual/motor processing speed, verbal memory and verbal learning (Torres et al., 2007; Van Der Werf-Eldering et al., 2011). Interestingly, neurocognitive deficits seem to represent a trait feature of BD since cognitive alterations h ave been detected during all phases of the illness (Cipriani et al., 2017; Martínez-Arán et al., 2000), even during euthymia (Bostock et al., 2017; Elias et al., 2017).

Source: Journal of Affective Disorders - July 23, 2018 Category: Neurology Authors: G.M. Mandolini, M. Lazzaretti, A. Pigoni, G. Delvecchio, J.C. Soares, P. Brambilla Tags: Mini review Source Type: research