A phase 1 study of chemosensitization with plerixafor plus G-CSF in adults with relapsed acute myeloid leukemia

Sensitization of leukemia cells and their progenitors by granulocytic growth factors may modulate the cell cycle kinetics of blast cells and is a tool to enhance the efficacy of chemotherapy in younger adults with acute myeloid leukemia (AML) [1,2]. Resistance to chemotherapy may be related to the adherence of leukemia cells to the stromal environment via specific receptor and adhesion molecules.In this setting, the CXCR4/SDF-1 axis functions as a main regulator of homing and retention of both normal and malignant hematopoietic cells in the bone marrow (BM) [3].
Source: Leukemia Research - Category: Hematology Authors: Tags: Letter to the Editor Source Type: research