Non-internal tandem duplication (ITD), non-tyrosine kinase domain (TKD) FLT3 mutations in myeloid malignancies: A brief report of 10 patients

Fms-like tyrosine kinase (FLT3) plays an essential role in hematopoiesis [1]. Its somatic mutations occur in approximately one-third of patients with acute myeloid leukemia (AML), and have important prognostic and therapeutic implications in myeloid malignancies, especially in AML [2 –4]. Two common subtypes of FLT3 mutations have been well described: internal tandem duplication (ITD) in the juxtamembrane and a recurrent amino acid substitution or deletion in the activation loop of the tyrosine kinase (TKD).

Source: Leukemia Research - July 21, 2018 Category: Hematology Authors: Alexandra Higgins, Abhishek Mangaonkar, Mehrdad Hefazi Torghabeh, David Viswanatha, Pedro Horna, James Foran, Naseema Gangat Tags: Letter to the Editor Source Type: research