Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells

GFRA1 and RET are overexpressed in estrogen receptor (ER)-positive breast cancers. Binding of GDNF to GFRA1 triggers RET signaling leading to ER phosphorylation and estrogen-independent transcriptional activation of ER-dependent genes. Both GFRA1 and RET are membrane proteins which are N-glycosylated but no O-linked sialylation site on GFRA1 or RET has been reported. We found GFRA1 to be a substrate of ST3GAL1-mediated O-linked sialylation, which is crucial to GDNF-induced signaling in ER-positive breast cancer cells.

Source: Cancer Letters - July 21, 2018 Category: Cancer & Oncology Authors: Tan-chi Fan, Hui Ling Yeo, Huan-Ming Hsu, Jyh-Cherng Yu, Ming-Yi Ho, Wen-Der Lin, Nai-Chuan Chang, John Yu, Alice L. Yu Tags: Original Articles Source Type: research