TPR Podcast Episode #6: I’m tripping and I can’t get down
TPR Podcast Episode 6: I’ve Tripped and I Can’t Get Down
Written by Theresa Kim, MD
Outline
1) Synthetic cathinones
2) Piperazine compounds
3) Gamma-hydroxybutyric acid (GHB)
4) 25C-NBOMe
This month’s podcast was inspired by the New York Times article “A Year After Drug Deaths, the Electric Zoo Music Festival Tries Again” which covered designer drug related deaths associated with summer music festivals
Synthetic Cathinones
Derivatives of the Catha edulis (khat) plant’s psychoactive alkaloid (cathinone)
o examples: mephedrone, methedrone, MDPV, methylone
o “bath salts” generally contained one or more synthetic cathinones
o Schneir et al performed a comprehensive analysis of the composition of “bath salts”, finding great variability in components and concentrations
Synthetic cathinones release norepinphrine, dopamine, serotonin
o Norepinephrine > sympathomimetic manifestations
o Serotonin > serotonin syndrome, hallucinations
o Dopamine > abuse potential
Routes: oral , nasal, parenteral
Effects: euphoria, agitation, paranoia, tachycardia, sweating, confusion, chest pain, palpitations, restlessness
Complications: hyponatremia, hyperpyrexia, serotonin syndrome, rhabdomyolysis, agitated delirium, multi-system failure
Treatment: supportive
o chemical restraint, aggressive cooling if indicated, fluids, anticipate potential complications
Piperazines
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Source: The Poison Review - Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news
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