D-Cycloserine Augmentation of Cognitive Behavior Therapy for Pediatric OCD: Predictors and Moderators of Outcome

Pediatric obsessive-compulsive disorder (OCD) is a disabling psychiatric illness that affects between 1 to 3% of children and significantly interferes in their academic, social, and familial functioning (Douglass et  al., 1995; Zohar, 1999). Fortunately, cognitive behavioral therapy (CBT) is an efficacious treatment for this debilitating condition (Freeman et al., 2014a; Watson and Rees, 2008). Much research has demonstrated that CBT outperforms non-active (e.g., waitlist; Bolton et al., 2011) and active (e .g., treatment-as-usual; relaxation training; Freeman et al., 2014b; Lewin et al., 2014) comparison conditions and the reduction in obsessive-compulsive symptom severity persists for up to seven-years following treatment (O'Leary et al., 2009).

Source: Journal of Affective Disorders - July 20, 2018 Category: Neurology Authors: Sabine Wilhelm, Noah Berman, Brent J. Small, Rachel Porth, Eric A Storch, Daniel Geller Tags: Research paper Source Type: research