GATA4 represses RANKL via multiple long-range enhancers to regulate osteoclast differentiation

GATA4 is a transcription factor that is responsible for tissue-specific gene regulation in many tissues, and more recent studies showed that it is necessary for osteoblast differentiation. Previously, we showed that in vivo deletion of Gata4 using Cre-recombinase under the control of the Col1a1 2.3  kb promoter, showed significantly reduced trabecular bone properties. To understand the role of GATA4 in more differentiated cells, GATA4fl/fl mice were crossed with mice expressing Cre-recombinase under the control of the osteocalcin promoter.

Source: Bone - July 19, 2018 Category: Orthopaedics Authors: Aysha B. Khalid, Alexandria V. Slayden, Jerusha Kumpati, Chanel D. Perry, Stuart B. Berryhill, Julie A. Crawford, Iram Fatima, Marco Morselli, Matteo Pellegrini, Gustavo A. Miranda-Carboni, Susan A. Krum Tags: Full Length Article Source Type: research