A genome-wide pathway enrichment analysis identifies brain region related biological pathways associated with intelligence
Intelligence is an important quantitative trait associated with human cognitive ability. The genetic basis of intelligence remains unclear now. Utilizing the latest chromosomal enhancer maps of brain regions, we explored brain region related biological pathways associated with intelligence. Summary data was derived from a large scale genome-wide association study (GWAS) of human, involving 78,308 unrelated individuals from 13 cohorts. The chromosomal enhancer maps of 8 brain regions were then aligned with the GWAS summary data to obtain the association testing results of enhancer regions for intelligence.
Source: Psychiatry Research - Category: Psychiatry Authors: Yanan Du, Yujie Ning, Yan Wen, Li Liu, Xiao Liang, Ping Li, Miao Ding, Yan Zhao, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Wenxing Yu, Shouye Hu, Xiong Guo, Feng Zhang Source Type: research