A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminemia receiving continuous venovenous hemodiafiltration

In the past few decades, numerous clinical studies have unequivocally demonstrated that pharmacokinetics (PK) of antimicrobials can be different in critically ill patients and a careful evaluation of all formulations intended for use in the critically ill should be performed in this specific patient population. For the newly introduced intravenous (IV) posaconazole preparation, only sparse data from critically ill patients exists. In one study, the PK profile of oral posaconazole in surgical intensive care unit (ICU) patients was found to be different from hematology patients, with lower plasma concentrations, higher clearance and an increased volume of distribution [1].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research