Human tuberculosis brain promotes neuronal apoptosis but not in astrocytes with high expression of vascular endothelial growth factor

The present study aimed to investigate the involvement of the angiogenic marker vascular endothelia growth factor (VEGF) and apoptotic markers of Bcl-2 and Bax in the neurons and astrocytes in the brain infected by Mycobacterium tuberculosis. The immunohistochemistry staining was performed to analyze the expression of the VEGF, Bcl-2 and Bax in the astrocytes and neurons. The expression of VEGF was high in neurons and astrocytes in both the infected brain and control tissues with no difference of angiogenic activity (p  = 0.40).

Source: Tuberculosis - July 18, 2018 Category: Respiratory Medicine Authors: Fatihah N. Othman, Sangu Muthuraju, Siti Suraiya M. Noor, Sarimah Abdullah, Abdul A.M. Yusoff, John Tharakan, Shalini Bhaskar, Mohd S. Mahmood, Fauziah Kassim, Md H. Rafia, Mohammed S.M. Haspani, Azmi Alias, Rogelio H. Pando, Jafri M. Abdullah, Hasnan Jaa Tags: Mechanisms of Pathogenesis Source Type: research