IMB-SD62, a triazolothiadiazoles derivative with promising action against tuberculosis

One lead 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole was identified as an inhibitor of shikimate dehydrogenase with antitubercular activity. Following up this compound, we optimized the lead through systematic modification of the 3 and 6 positions. The antitubercular activities in vitro, shikimate dehydrogenase inhibitory activities and cytotoxicity of derivatives were determined. We found IMB-SD62 with lower cytotoxicity and better activity. Thus, we studied the in vivo efficacy of IMB-SD62 against Mycobacterium tuberculosis and pharmacokinetics of IMB-SD62.

Source: Tuberculosis - July 17, 2018 Category: Respiratory Medicine Authors: Qi Deng, Jianzhou Meng, Yishuang Liu, Yan Guan, Chunling Xiao Source Type: research