Dermal Interstitial Alterations in Patients With Heart Failure and Reduced Ejection Fraction: A Potential Contributor to Fluid Accumulation? [Original Articles]

Conclusions: Interstitial glycosaminoglycan concentration is significantly increased in HFrEF patients compared with healthy subjects and correlated with tissue water content and clinical signs of volume overload. A better appreciation of the interstitial compartment might improve management of volume overload in HF.

http://circheartfailure.ahajournals.org/cgi/content/short/11/7/e004763?rss=1

Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Nijst, P., Olinevich, M., Hilkens, P., Martens, P., Dupont, M., Tang, W. H. W., Lambrichts, I., Noben, J.-P., Mullens, W. Tags: Pathophysiology, Heart Failure Original Articles Source Type: research