125I-Insulin and 125I-Insulinlike Growth Factor-I in Chicken Hepatocytes Internalization. The Peptides Distribution and Action in Birds

Conclusions: 125I-insulin and 125I-IGF-I distribution is a specific characteristic of internalization, which is capable of changing, despite retaining basic internalization characteristics of both insulin and IGF-I in the cells of different animal species. The differences of 125I-insulin and 125I-IGF-I distribution types in chicken and rat cells, allow us to guess correctly other functional roles of insulin and IGF-I in birds as compared with mammals.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research