Microbial Efflux Pump -Specific Determinant to Fight Against the Antimicrobial Resistance in Pathogenic Strains

Conclusion: The structure studies assist to design new drug compound which can efficiently inhibit the efflux pump and provide promising efflux pump inhibitor to cure multidrug resistance caused by the bacterial community. 3D structure of the efflux pump reveals the drug binding site and drug dislodge-ment site. The efflux pump inhibitor reduces the necessity of discovering novel drug molecules and provides a new way to reutilize existing drug with slight modifications.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research