Role of Structural Flexibility of HIV-1 Integrase in the Design of Potent Anti-HIV Drugs

Conclusion: Due to nonavailability of HIV-1 integrase in the crystalline form, we have to use the approach of analogue crystal, for example, PFV integrase. Although there are a drastic difference in the structural features in HIV-1 and PFV integrase. Researchers have to depend on PFV integrase for developing HIV-1 integrase inhibitors by trial and error process.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research