Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy

Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+) dependent enzymes that regulate cellular functions through deacetylation of protein targets. They have roles in both the periphery and central nervous system and have been implicated in depression biology. A recent genome-wide association study has identified a locus for major depression in the Sirtuin1 gene (SIRT1) and lower blood levels of SIRT1 mRNA in patients with depression have also been observed in two studies. To our knowledge, no studies have examined the effect of treatment on SIRT1 levels in patients with depression.

Source: European Neuropsychopharmacology - July 15, 2018 Category: Psychiatry & Psychology Authors: Claire L. McGrory, Karen M. Ryan, Erik Kolshus, Martha Finnegan, Declan M. McLoughlin Source Type: research