Identification of TGF β-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets

Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features of OA, including chondrocyte hypertrophy and focal calcification of articular cartilage, resemble the endochondral ossification processes. Alterations in transforming growth factor β (TGFβ) signaling have been associated with OA as well as with chondrocyte hypertrophy. Our aim was to identify novel candidate genes implicated in chondrocyte hypertrophy during OA pathogenesis by determining which TGFβ-related genes are regulated during murine OA and endochondral ossification.

Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Laurie M.G. de Kroon, Guus G.H. van den Akker, Bent Brachvogel, Roberto Narcisi, Daniele Belluoccio, Florien Jenner, John F. Bateman, Christopher B. Little, Pieter Brama, Esmeralda N. Blaney Davidson, Peter M. van der Kraan, Gerjo J.V.M. van Osch Tags: Full Length Article Source Type: research