Cancer prevention in hereditary colorectal cancer syndromes: Chemoprevention and lifestyle changes

Lynch Syndrome (LS) and familial adenomatous polyposis (FAP) represent the most prevalent inherited colorectal cancer syndromes. The key to reducing morbidity and mortality in affected individuals is prevention, and there is interest in chemopreventive agents that can either delay or prevent the need for procedural or surgical interventions. Sulindac is supported as a chemopreventive agent for the reduction of colorectal and duodenal polyps, as well as desmoids, in FAP. Aspirin has shown benefit in reducing polyp burden in LS.
Source: Seminars in Colon and Rectal Surgery - Category: Gastroenterology Authors: Source Type: research