The virtuous self-tolerance of virtual memory T cells

"Virtual" memory CD8+ T cells are a subset of immune cells produced by homeostatic mechanisms involving response to self-antigens, raising the possibility that these cells could mediate autoimmunity. New work by Drobek et al demonstrates that virtual memory T cells are indeed favored by stronger T-cell receptor signals but exhibit minimal autoreactivity while maintaining self-tolerance.

Source: EMBO Journal - July 13, 2018 Category: Molecular Biology Authors: Truckenbrod, E. N., Jameson, S. C. Tags: Immunology News [amp ] Views Source Type: research