Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis

Conclusion: Our studies provide insights into a novel mechanism by which epithelial TGF? signaling modulates the tumor microenvironment, and by which it is involved in lung metastasis in HER2+ breast cancer patients. The effects of pharmacological targeting of the TGF? pathway in vivo during tumor progression remain controversial. The targeting of TGF? signaling should be a viable option, but because VEGF has a protumorigenic effect on HER2+ tumors, the targeting of this protein could be considered when it is associated with attenuated TGF? signaling.

http://breast-cancer-research.com/content/16/5/425

Source: Breast Cancer Research - October 4, 2014 Category: Cancer & Oncology Authors: Sergey NovitskiyElizabeth ForresterMichael PickupAgnieszka GorskaAnna ChytilMary AakreDina PolosukhinaPhilip OwensDilyara YusupovaZhiguo ZhaoFei YeYu ShyrHarold Moses Source Type: research