Phosphorylation of protein kinase B, the key enzyme in insulin signalling cascade, is enhanced in linoleic and arachidonic acid treated HT29 and HepG2 cells

Alterations of polyunsaturated fatty acid (PUFA) membrane composition have been proposed to alter cellular functions including cellular response to insulin. Defects in insulin signalling pathway are responsible for insulin resistance and type 2 diabetes [1 –3], thus the understanding of insulin transduction pathway is of clinical importance.

Source: Nutrition - July 12, 2018 Category: Nutrition Authors: Katia Mariniello, Yoeju Min, Kebreab Ghebremeskel Source Type: research