Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?

This study investigated the effect of “dose” and the components of Cognitive Behavioral Therapy (CBT) on treatment effects. It is a secondary analysis of the ACTION (Assessment of Cognitive Therapy Instead of Neuroleptics) trial which investigated CBT for people with schizophrenia spectrum disorders that chose not to take antipsycho tic medication. Using instrumental variable methods, we found a “dose-response” such that each CBT session attended, reduced the primary outcome measure (the PANSS total score) by approximately 0.6 points (95% CI −1.20 to −0.06, p = 0.031).

Source: Schizophrenia Research - July 11, 2018 Category: Psychiatry Authors: Helen M. Spencer, Martina McMenamin, Richard Emsley, Douglas Turkington, Graham Dunn, Anthony P. Morrison, Alison Brabban, Paul Hutton, Robert Dudley Source Type: research