Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery

Publication date: April 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 2Author(s): Sadia Gilani, Sadullah Mir, Momina Masood, Abida Kalsoom Khan, Rehana Rashid, Saira Azhar, Akhtar Rasul, Muhammad Nadeem Ashraf, Muhammad Khurram Waqas, Ghulam MurtazaAbstractThe purpose of this study was to fabricate a triple-component nanocomposite system consisting of chitosan, polyethylene glycol (PEG), and drug for assessing the application of chitosan–PEG nanocomposites in drug delivery and also to assess the effect of different molecular weights of PEG on nanocomposite characteristics. The casting/solvent evaporation method was used to prepare chitosan–PEG nanocomposite films incorporating piroxicam-β-cyclodextrin. In order to characterize the morphology and structure of nanocomposites, X-ray diffraction technique, scanning electron microscopy, thermogravimetric analysis, and Fourier transmission infrared spectroscopy were used. Drug content uniformity test, swelling studies, water content, erosion studies, dissolution studies, and anti-inflammatory activity were also performed. The permeation studies across rat skin were also performed on nanocomposite films using Franz diffusion cell. The release behavior of films was found to be sensitive to pH and ionic strength of release medium. The maximum swelling ratio and water content was found in HCl buffer pH 1.2 as compared to acetate buffer of pH 4.5 and phosphate buffer pH 7.4. The release rate constants obtained fro...
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research