Cognitive effects of mifepristone in overweight, euthymic adults with depressive disorders

Individuals with mood disorders are known to exhibit high cortisol levels (Young, 2004; Young et al., 2004; Sapolsky, 2000). Cortisol, a glucocorticoid released by the adrenal cortex in response to stress, is a negative regulator of the hypothalamic-pituitary-adrenal (HPA) axis (Young, 2004; Tatomir et al., 2014). Dysregulation of the HPA axis results in elevated cortisol levels, which are thought to contribute to the depressive symptoms and cognitive impairment associated with mood disorders (Young, 2004; Tatomir et al., 2014; Wolkowitz et al., 1990; Sapolsky, 2000).

Source: Journal of Affective Disorders - July 10, 2018 Category: Neurology Authors: S Roat-Shumway, TE Wroolie, K Watson, AF Schatzberg, NL Rasgon Tags: Research paper Source Type: research