Clinical significance of novel SH2B3 mutations in adult Chinese acute lymphoblastic leukemia patients

In B cell acute lymphoblastic leukemia (ALL), the abnormal activation of the JAK-STAT signaling pathway is thought to play a very important role in pathogenesis. This pathway involves a series of target genes such as IKZF1, JAK, CRLF2, IL7R and SH2B adapter protein 3 (SH2B3). SH2B3, also known as lymphocyte adapter protein (LNK), can negatively regulate the activation of multiple tyrosine kinase signaling pathways and cytokine signaling pathways. It also plays a significant role in the development and differentiation of hematopoietic cells [1].

Source: Leukemia Research - July 10, 2018 Category: Hematology Authors: Yan Gu, Qi Han, Mary McGrath, Chunhua Song, Zheng Ge Tags: Letter to the Editor Source Type: research