Are clonal cells circulating in the peripheral blood of myelodysplastic syndrome?: Quantitative comparison between bone marrow and peripheral blood by targeted gene sequencing and fluorescence in situ hybridization

The diagnostic criteria of myelodysplastic syndrome (MDS) is based on peripheral cytopenia and dysplasia of hematopoietic cells in ≥ 10% in bone marrow (BM) [1]. Cytogenetics and molecular results are used complementarily and in conjunction with the above criteria. Treatment responses are also based on the peripheral hemogram, the changes of blasts % and cytogenetic changes in BM [2]. Practically, the determination of treatme nt response requires BM study for the evaluation of blast % and cytogenetics, and invasiveness of BM study hampers the close monitoring of treatment response.

Source: Leukemia Research - July 10, 2018 Category: Hematology Authors: Sang Mee Hwang, Kyongok Im, Yoon Hwan Chang, Hee Sue Park, Jung-Ah Kim, Sung Min Kim, Dong Soon Lee Tags: Correspondence Source Type: research