Prognostic impact of ASXL1 mutations in patients with myelodysplastic syndromes and multilineage dysplasia with or without ring sideroblasts

The 2016 World Health Organization (WHO) classification of myeloid neoplasms reclassified patients with myelodysplastic syndromes (MDS) with multilineage dysplasia (MLD) based on presence or absence of ring sideroblasts (RS). We performed this study to validate this change in the context of relevant gene mutations.

Source: Leukemia Research - July 10, 2018 Category: Hematology Authors: Abhishek A. Mangaonkar, Naseema Gangat, Aref Al-Kali, Michelle A. Elliott, Kebede H. Begna, Curtis A. Hanson, Rhett P. Ketterling, Alexandra P. Wolanskyj-Spinner, William J. Hogan, Mark R. Litzow, Mrinal M. Patnaik Source Type: research