β-Carboline Derivatives as Novel Antivirals for Herpes Simplex Viruses

Herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) are dsDNA human herpes viruses that belong to Alphaherpesvirinae. They are transmitted across epithelial mucosal cells as well as through skin lesions. These viruses migrate along axons towards neuronal ganglia, where they persist in a latent state and may reactivate several times during an individual's lifespan. HSV-1 predominantly causes orofacial lesions, whereas HSV-2 mainly infects the genital mucosa [1].

Source: International Journal of Antimicrobial Agents - July 10, 2018 Category: Drugs & Pharmacology Authors: Gonzalez M. Micaela, Cabrerizo Franco M, Baiker Armin, Erra-Balsells Rosa, Osterman Andreas, Nitschko Hans, Vizoso-Pinto Mar ía G. Source Type: research