Secular trends in the age at onset of bipolar I disorder – Support for birth cohort effects from interational, multi-centre clinical observational studies

ConclusionsIn BD-I cases diagnosed according to internationally recognized criteria and recruited to pan-European clinical observational studies, the AAO distributions are compatible with a birth cohort effect. A potentially modifiable risk factor, namely ASUD status, was associated with the observed reduction in AAO, especially in males.
Source: European Psychiatry - Category: Psychiatry Source Type: research