Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development

Publication date: August 2018Source: European Psychiatry, Volume 52Author(s): Paulina Wigner, Piotr Czarny, Ewelina Synowiec, Michał Bijak, Monika Talarowska, Piotr Galecki, Janusz Szemraj, Tomasz SliwinskiAbstractNumerous data suggests that the disorders of tryptophan catabolites (TRYCATs) pathway, including a decreased level of tryptophan or evaluated concentration of harmful TRYCATs −kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, 3-hydroxytryptophan − may cause the occurrence of DD symptoms. In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development. Our study was performed on the DNA isolated from peripheral blood of 281 depressed patients and 236 controls. We genotyped, by using TaqMan probes, four polymorphisms: c.*456G> A of KAT1 (rs10988134), c.975-7T> C of AADAT (rs1480544), c.-1849C> A (rs3824259) and c.-1493G> C(rs10089084)of IDO1. We found that only the A/A genotype of c.*456G> A − KAT1 (rs10988134) increased the risk of depression occurrence. Interestingly, when we stratified the study group according to gender, this relationship was present only in male population. However, a gene–gene analysis revealed a link between the T/T-C/C genotype of c.975-7T> C − AADAT (rs1480544)or c.-1493G> C − IDO1 (rs10089084) and C/C-C/A genotype of c.975-7T> C − AADAT (rs1480544)and c. −1849C> A − IDO1 (rs3824259) and the disease. Moreover, we fou...
Source: European Psychiatry - Category: Psychiatry Source Type: research