Impact of Apo E gene polymorphism on HCV therapy related outcome in a cohort of HCV Egyptian patients

Conclusion: This study supports the hypothesis of the protective impact of Apo E4 allele that favors viral clearance of HCV infection and its recovery after combined therapy, while the Apo E3 allele is considered as a particular risk factor for the chronicity in HCV patients and resistance to therapy. Whereas the Apo E2 allele confers a resistance to HCV infection at a time of exposure.
Source: Journal of Genetic Engineering and Biotechnology - Category: Biotechnology Source Type: research