Cryptococcose neuroméningée chez des patients infectés par le VIH au Centre Hospitalier Régional d’Agadir (région Souss-Massa, Maroc)

ConclusionLa CNM est une infection opportuniste grave chez les patients infectés par le VIH, et le taux de létalité demeure inacceptable. La lutte contre la CNM chez les patients à VIH+ impose un diagnostic précoce, un accroissement de l’accès aux antirétroviraux et une instauration rapide d’un traitement adapté et une prescription d’antifongiques systémiques efficaces.SummaryIntroductionNeuromeningeal cryptococcosis (NMC) is a severe and fatal opportunistic infection. Lethality is frequent in the absence of treatment, especially in the presence of HIV co-infection.ObjectiveTo determine the prevalence, epidemiological, clinical, biological and therapeutic aspects as well as the evolution of NMC for patients infected with HIV.Patients and methodsThis is a retrospective study of 40 cases of neuromeningeal cryptococcosis diagnosed in HIV-infected patients. Data are collected for 7 years (from January 2010 to December 2016) in the registers of the parasitology laboratory and the infectious diseases department at the regional hospital center in Agadir.ResultsA reduction in the prevalence of neuromeningeal cryptococcosis in HIV-infected patients was noted from 2010 to 2016 (3.66% to 0.83%). The overall prevalence of NMC was 1.53%. The mean age was 37 ± 10 years old, with 90% of patients aged less than 45 years. The main clinical symptomatology was headache (75%). The main cytochemical abnormalities of cerebrospinal fluid analysis were hyperproteinorachy (6...
Source: Journal of Medical Mycology - Category: Biology Source Type: research