DGKζ ablation engenders upregulation of p53 level in the spleen upon whole-body ionizing radiation

This study was conducted to elucidate this point using an experiment with DGKζ-KO mice under DNA damage induced by whole-body ionizing radiation. Our results reveal that p53 protein is induced robustly in the spleen of DGKζ-KO mice upon exposure to ionizing radiation, thereby promoting apoptosis in this organ. Taken together, the results demonstrate that DGKζ plays a sentinel role in p53 expression at the cellular and organismal levels after DNA damaging stress conditions.

Source: Advances in Biological Regulation - July 11, 2018 Category: Biology Source Type: research