Mellein, a dihydroisocoumarin with bioherbicidal activity from a new strain of Lasiodiplodia pseudotheobromae C1136

Publication date: Available online 4 June 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Charles Oluwaseun Adetunji, Julius Kola Oloke, Mishra Pradeep, A. Peter Oluyori, Ravinder Singh Jolly, Oluwasesan Micheal BelloAbstractThe use of synthetic herbicides poses a serious threat to environment, health and food safety. The development of safe and effective bioherbicides for selective control of weeds is thus the primary concern in crop production around the world. Efforts are being made to investigate the use of a safe, ecofriendly and highly selective herbicides from biological origin. Coumarin and its derivatives are natural compounds renowned for their phytotoxic potential.Mellein, a dihydroisocoumarin designated as (R)-8-hydroxy-3-methylisochroman-1-one was isolated as an active metabolite from the broth of a new strain (this strain is one of the best among phytopathogenic strains collected) of Lasiodiplodia pseudotheobromae. The structural characterization of the compound was achieved by using combined spectroscopic analysis i.e. 1D and 2D NMR and LC–MS. The host range study was carried-out against plants from Cucurbitaceae, Solanaceae and Leguminosae, Poaceae and Valerianaceae families, the isolated phytotoxic metabolite from Lasiodiplodia pseudotheobromae at a concentration 10 µg/µl showed selective inhibition at 56%–66% against the latter two families only when inoculated.Hence, purified compound from Lasiodiplodia pseudotheobro...
Source: Beni Suef University Journal of Basic and Applied Sciences - Category: Science Source Type: research