Evaluation of endometrial scratching on intrauterine insemination outcome and endometrial receptivity

Publication date: Available online 18 May 2018Source: Middle East Fertility Society JournalAuthor(s): Vasudha Gupta, Gita Radhakrishnan, Vinod Arora, Alpana SinghAbstractObjectiveEvaluation of endometrial scratching on pregnancy rates after IUI and comparing levels and distribution of IL-6 (inflammatory molecule) and E-Cadherin (adhesion molecule) by immunohistochemistry.Study designRandomized case control study.SettingTertiary care hospital of Delhi, India.Material and methods240 women (120 in each group) with previous failed IUI cycles were enrolled. Study group patients were subjected to endometrial scratch by “Pipelle” on postovulatory day 6–8 in the preceding cycle. IUI was performed after controlled ovarian stimulation with gonadotropins. 20 patients of study group in whom IUI was cancelled underwent repeat scratch on postovulatory day 6–8. Levels and distribution of IL-6 and E-Cadherin were evaluated by Immunohistochemistry before and after the scratch.Main outcomeComparison of pregnancy rates in women undergoing IUI after endometrial scratching with women undergoing IUI alone.Results and conclusionThere were 19 (19%) clinical pregnancies in the study group and 8 (7.6%) in the control group. There was a significant difference in between both the groups (p = 0.022). Number of pregnancies in unexplained infertility patients was 22.66% in study and 9.5% in control group (p = 0.0291). There was significant increase in score for IL-6 and E-Cadherin in both g...
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research