Protective effect of calcitriol on podocytes in spontaneously hypertensive rat

ConclusionThe present results indicated that there was injury of podocytes in hypertensive nephropathy, which can be ameliorated by calcitriol in SHR, but there was no significant anti-hypertensive effect. Vitamin D/VDR decreased proteinuria perhaps by increasing expression of nephrin and WT1 protein in podocyte of SHRs.
Source: Journal of the Chinese Medical Association - Category: General Medicine Source Type: research