Constrained cell penetrating peptides

Publication date: December 2017Source: Drug Discovery Today: Technologies, Volume 26Author(s): S.A. Bode, D.W.P.M. LöwikIn this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties – one of the big challenges – by means of restraining them. Three different constraining strategies are presented: triggerable activation, backbone rigidification and macrocyclization. Each of these methods have their opportunities in gaining control over CPP activity and selectivity.

Source: Drug Discovery Today: Technologies - July 10, 2018 Category: Drugs & Pharmacology Source Type: research