Integrating biocatalysis and multicomponent reactions

Publication date: Available online 28 June 2018Source: Drug Discovery Today: TechnologiesAuthor(s): Chiara Lambruschini, Andrea Basso, Luca BanfiWhile often multicomponent reactions (MCR) are used for the diversity-oriented synthesis of racemic (or achiral) molecular entities, this short review describes two alternative approaches for accessing enantiopure products exploiting the power of biocatalysis. Enzymes or microorganisms may be used for preparing enantiopure MCR inputs or for resolving racemic (or achiral) MCR adducts.Graphical abstract

Source: Drug Discovery Today: Technologies - July 10, 2018 Category: Drugs & Pharmacology Source Type: research